Table 3.

Analysis about the risk of acute hospitalization after 1 year of follow-up with regards to having or not different complications (N = 605)

	Unadjusted HR (95% CI)	p	Adjusted HR(95% CI)	p
Motor fluctuations	2.616 (1.329–5.148)	0.005	2.461 (1.065–5.678)	0.035
Dyskinesia	2.792 (1.365–5.711)	0.005	2.145 (0.905–5.085)	0.083
Severe or very severe NMSB (NMSS > 40)	2.871 (1.400–5.890)	0.004	2.645 (1.154–6.103)	0.022
Very severe NMSB (NMSS > 70)	2.925 (1.477–5.791)	0.002	2.828 (1.319–6.063)	0.008
FOG	1.489 (0.757–2.930)	0.249	1.117 (0.496–2.518)	0.789
Falls	3.262 (1.590–6.696)	0.001	3.966 (1.757–8.470)	0.001
Dysphagia	2.843 (1.450–5.575)	0.002	2.356 (1.124–4.941)	0.023
Major depression	2.159 (1.033–4.515)	0.041	1.934 (0.855–4.377)	0.113
Cognitive impairment (PD-CRS≤84)	1.493 (0.743–3.002)	0.260	1.160 (0.514–2.615)	0.721
HY-OFF from 3 to 5	1.331 (0.463–3.826)	0.595	0.703 (0.187–1.719)	0.602
UPDRS-III-OFF > 20	2.800 (1.258–6.233)	0.012	3.644 (1.430–9.284)	0.007*
Functional dependency	2.118 (0.877–5.116)	0.095	1.894 (0.675–5.318)	0.225

Age, gender, disease duration, LEDD (levodopa equivalent daily dose), total number of non-anti parkinsonian drugs (as a marker of comorbidity) and UPDRS-III-OFF were included in the model as covariates. ^*For this analysis the UPDRS-III-OFF was not included in the model. FOG, freezing of gait; HR, Hazard ratio; NMSB, non-motor symptoms burden; NMSS, Non-Motor Symptoms Scale; PD-CRS, Parkinson’s Disease Cognitive Rating Scale; UPDRS, Unified Parkinson’s Disease Rating Scale.