Figure 5.

Comparison of AAV5 (green) and AAV4 (orange) at selected variable regions (VR) where PKD1 (yellow) interacts with AAV5. Amino-acid sequence alignments for each VR are provided below the set of structures, with numbers showing the first and last residues of the VR (according to VP1 numbering); residues of interest extending beyond the variable region are supplied after the number; contact residues are shown in green, while clashing residues are shown in red. Residues extending beyond VR-IX are shown in the VR-IX alignment. Residues of interest are labeled on the structures and underlined in the alignment. The clash between AAVR and AAV4 for VR-VII is surrounded by a circle to highlight its presence.