Table 4. Free energies of binding for the four PKD12–AAV complexes calculated with MM/PBSA.

	ΔH (kcal mol−1)	−TΔS (kcal mol−1)	ΔG (kcal mol−1)
AAV5–PKD1	−52.79	27.62	−25.17
AAV4–PKD1	−22.35	26.77	4.42
ΔΔG			29.59
AAV9–PKD2	−38.08	31.50	−6.58
AAV4–PKD2	−32.08	36.92	4.84
ΔΔG			11.42