Table 4.
Laboratory data with preexisting statin use and nonuse in the unmatched cohort of coronavirus disease 2019 patients
| Laboratory data | Prehospital use of statins | ||||
| Yes | No | P-value | |||
| n | Mean (SD) | n | Mean (SD) | ||
| Inflammatory response | |||||
| ESR (mm/h) | 893 | 62.9 (±35.45) | 2056 | 58.17 (±35.68) | 0.41 |
| CRP (mg/l) | 4032 | 96.87 (±98.37) | 9324 | 100.39 (±111.29) | 0.01 |
| High-sensitivity CRP (mg/l) | 299 | 96.76 (±82.07) | 694 | 104.39 (±82.34) | 0.03 |
| Ferritin (ng/ml) | 3645 | 930.20 (±2330.15) | 8463 | 993.63 (±2735.89) | 0.09 |
| IL-6 (pg/ml) | 297 | 266.58 (±623.78) | 739 | 197.16 (±484.44) | <0.001 |
| Hematologic profile | |||||
| Hemoglobin concentration (g/dl) | 8735 | 12.45 (±2.10) | 19 839 | 12.83 (±2.19) | <0.001 |
| Leukocyte count (103 cells/μl) | 8663 | 11.59 (±9.44) | 19 889 | 11.31 (±7.38) | 0.01 |
| Neutrophil count (103 cells/μl) | 6438 | 8.82 (±5.69) | 14 531 | 8.78 (±5.78) | 0.93 |
| Lymphocyte count (103 cells/μl) | 6699 | 1.44 (±4.57) | 15 367 | 1.47 (±2.32) | 0.18 |
| Platelet count (103 cells/μl) | 8611 | 280.75 (± 25.11) | 19 524 | 295.23 (±133.10) | <0.001 |
| Coagulation profile | |||||
| aPTT (s) | 2177 | 56.10 (±45.72) | 4842 | 52.97 (±42.48) | <0.001 |
| PT (s) | 2446 | 16.53 (±13.38) | 5353 | 15.05 (±10.02) | <0.001 |
| INR (s) | 370 | 1.51 (±1.10) | 941 | 1.37 (±0.85) | <0.001 |
| Fibrinogen (mg/dl) | 540 | 509.39 (±198.46) | 1427 | 516.80 (±208.03) | 0.27 |
| D-dimer (μg/ml) | 4435 | 3.99 (±15.63) | 10 177 | 3.67 (±10.11) | 0.26 |
| Metabolic profile | |||||
| pH | 2566 | 7.43 (±0.09) | 5843 | 7.44 (±0.09) | 0.06 |
| paO2 (mmHg) | 2691 | 110.33 (±73.16) | 5914 | 114.49 (±80.29) | <0.001 |
| paCO2 (mmHg) | 2761 | 47.01 (±20.46) | 6038 | 48.06 (±21.04) | 0.05 |
| Lactic acid (mmol/l) | 3197 | 2.29 (±2.36) | 7355 | 2.31 (±2.49) | 0.07 |
| LDH (U/l) | 3554 | 467.18 (±685.56) | 8221 | 473.12 (±1139.30) | 0.70 |
| Renal profile | |||||
| BUN (mg/dl) | 8803 | 37.86 [±28.43) | 19 679 | 31.09 (±27.55) | <0.001 |
| Creatinine (mg/dl) | 8970 | 1.49 (±1.25) | 19 924 | 1.28 (±1.23) | <0.001 |
| Lipid profile | |||||
| LDL (mg/dl) | 493 | 64.09 (±30.76) | 1098 | 80.52 (±35.85) | <0.001 |
| VLDL (mg/dl) | 99 | 24.12 (±10.62) | 195 | 26.69 (±14.08) | 0.01 |
| Liver profile | |||||
| AST (U/l) | 6815 | 121.05 (±721.08) | 15 462 | 129.44 (±824.58) | 0.28 |
| ALT (U/l) | 6816 | 91.66 (±410.19) | 15 366 | 101.18 (±375.97) | 0.43 |
| Total bilirubin (mg/dl) | 6769 | 0.75 (±0.89) | 15 440 | 0.82 (±1.46) | <0.001 |
ALT, alanine aminotransaminase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransaminase; BUN, blood urea nitrogen; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; IL-6, interleukin 6; INR, international normalized ratio; LDH, lactate dehydrogenase; LDL, low-density lipoprotein; paCO2, partial arterial carbon dioxide; paO2, partial arterial oxygen; PT, prothrombin time; VLDL, very low-density lipoprotein.