Table 6.
Susceptibility of multidrug-resistant pathogens to antibiotics
| All pathogen isolates | Klebsiella spp. isolates | Pseudomonas spp. isolates | Enterobacter spp. isolates | |
|---|---|---|---|---|
| Pathogen level (isolates) | ||||
| Gram-negative bacterial pathogens with susceptibility data | 531 | 332 | 65 | 37 |
| Antibiotic resistancea | ||||
| Carbapenems | 438 (76.9) | 269 (88.5) | 56 (80.4) | 33 (66.7) |
| Gram-negative multi-resistant pathogens, n (%) | 364 (68.5) | 252 (75.9) | 45 (69.2) | 28 (75.6) |
| Antibiotic resistancea | ||||
| n (pathogens) | 364 | 252 | 45 | 28 |
| Aminoglycosides | 352 (65.1) | 249 (68.7) | 38 (57.9) | 28 (53.6) |
| Amphenicol | 16 (75.0) | 13 (84.6) | ||
| Carbapenems | 355 (89.3) | 250 (92.4) | 42 (95.2) | 27 (81.5) |
| Doripenem | 63 (96.8) | 53 (96.2) | 4 (100) | 1 (100) |
| Ertapenem | 208 (86.1) | 163 (91.4) | – | 22 (77.3) |
| Imipenem | 254 (71.7) | 188 (71.3) | 24 (100) | 19 (57.9) |
| Meropenem | 323 (80.8) | 228 (82.9) | 42 (92.9) | 22 (68.2) |
| Cephalosporins | 343 (97.4) | 240 (98.8) | 44 (88.6) | 26 (100) |
| Cephalosporin/beta-lactamase inhibitor | 222 (18.5) | 155 (18.1) | 26 (23.1) | 20 (10.0) |
| Ceftazidime/avibactam | 219 (7.8) | 154 (9.1) | 25 (4.0) | 20 (5.0) |
| Cefoperazone/sulbactam | 14 (85.7) | 9 (100) | 3 (33.3) | |
| Ceftolozane/tazobactam | 39 (61.5) | 20 (80.0) | 16 (31.3) | 1 (100) |
| Glycylcycline | 139 (39.6) | 117 (42.7) | 4 (100) | 9 (0.0) |
| Monobactam | 99 (76.8) | 72 (84.7) | 16 (56.3) | 6 (33.3) |
| Penicillins | 147 (98.0) | 112 (100) | 4 (50.0) | 18 (100) |
| Penicillins and beta-lactamase inhibitors | 325 (97.8) | 232 (98.3) | 37 (97.3) | 25 (100) |
| Ampicillin–sulbactam | 80 (98.8) | 61 (98.4) | 3 (100) | 8 (100) |
| Amoxicillin–clavulanate | 146 (98.6) | 118 (99.2) | – | 12 (100) |
| Piperacillin–tazobactam | 232 (90.9) | 153 (93.5) | 37 (91.9) | 21 (90.5) |
| Ticarcillin–clavulanate | 8 (62.5) | 4 (100) | 1 (0.0) | 1 (0.0) |
| Fluoroquinolones | 329 (90.6) | 228 (96.1) | 40 (80.0) | 24 (70.8) |
| Tetracycline | 19 (52.6) | 17 (52.9) | 1 (0.0) | |
| Colistin | 175 (25.7) | 126 (31.7) | 24 (8.3) | 16 (12.5) |
| Trimethoprim-sulfamethoxazole | 152 (79.6) | 113 (83.2) | 3 (100) | 19 (68.4) |
| Fosfomycin | 140 (45.0) | 111 (44.1) | 5 (100) | 16 (31.3) |
| Nitrofurantoin | 21 (42.9) | 17 (41.2) | – | 3 (33.3) |
Susceptibility data for pathogens identified at the latest sampling time before the start of ceftazidime–avibactam, by genus. Each table cell gives the number of isolates tested against the particular antibiotic (or class) followed in brackets by the percentage of isolates which were found resistant to the particular antibiotic (or class)