Table 4.
Genotype frequencies (presence of mutation or not) in patients showing pCR versus those not showing pCR for 21 SNPs. p-value corresponds to Fisher’s exact test. Significant value is highlighted in bold. w = wild-type allele and v = variant allele.
| SNP (Gene or Region) |
Presence of Mutation (No = ww Yes = wv + vv) |
Patients | No pCR | pCR | p-Value | |||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | |||
| rs1045642 (ABCB1) |
ww | 10 | 20 | 7 | 20 | 3 | 20 | 1.000 |
| wv + vv | 40 | 80 | 28 | 80 | 12 | 80 | ||
| rs11212617 (ATM) |
ww | 10 | 20.41 | 8 | 22.86 | 2 | 14.29 | 0.702 |
| wv + vv | 39 | 79.59 | 27 | 77.14 | 12 | 85.71 | ||
| rs2070096 (BARD1) |
ww | 36 | 75 | 28 | 84.85 | 8 | 53.33 | 0.031 |
| wv + vv | 12 | 25 | 5 | 15.15 | 7 | 46.67 | ||
| rs62568637 (BRINP1) |
ww | 47 | 95.92 | 34 | 97.14 | 13 | 92.86 | 0.494 |
| wv + vv | 2 | 4.08 | 1 | 2.86 | 1 | 7.14 | ||
| rs1001179 (CAT) |
ww | 27 | 62.79 | 19 | 63.33 | 8 | 61.54 | 1.000 |
| wv + vv | 16 | 37.21 | 11 | 36.67 | 5 | 38.46 | ||
| rs2293347 (EGFR) |
ww | 42 | 84 | 29 | 82.86 | 13 | 86.67 | 1.000 |
| wv + vv | 8 | 16 | 6 | 17.14 | 2 | 13.33 | ||
| rs396991 (FCGR3) |
ww | 17 | 34.69 | 13 | 37.14 | 10 | 71.43 | 0.743 |
| wv + vv | 32 | 65.31 | 22 | 62.86 | 8 | 53.33 | ||
| rs1695 (GSTP1) |
ww | 24 | 51.06 | 14 | 43.75 | 10 | 66.67 | 0.212 |
| wv + vv | 23 | 48.94 | 18 | 56.25 | 5 | 33.33 | ||
| rs121913471 (HER2) |
ww | 48 | 97.96 | 34 | 97.14 | 14 | 100 | 1.000 |
| wv + vv | 1 | 2.04 | 1 | 2.86 | ||||
| rs1058808 (HER2) |
ww | 11 | 25 | 6 | 20 | 5 | 35.71 | 0.287 |
| wv + vv | 33 | 75 | 24 | 80 | 9 | 64.29 | ||
| rs1136201 (HER2) |
ww | 35 | 70 | 24 | 68.57 | 11 | 73.33 | 1.000 |
| wv + vv | 15 | 30 | 11 | 31.43 | 4 | 26.67 | ||
| rs2229046 (HER3) |
ww | 41 | 85.42 | 28 | 82.35 | 13 | 92.86 | 0.656 |
| wv + vv | 7 | 14.58 | 6 | 17.65 | 1 | 7.14 | ||
| rs773123 (HER3) |
ww | 41 | 83.67 | 28 | 82.35 | 13 | 86.67 | 1.000 |
| wv + vv | 8 | 16.33 | 6 | 17.65 | 2 | 13.33 | ||
| rs7698718 (LINC01060) |
ww | 20 | 57.14 | 15 | 60 | 5 | 50 | 0.712 |
| wv + vv | 15 | 42.86 | 10 | 40 | 5 | 50 | ||
| rs55756123 (LDB2) |
ww | 48 | 97.96 | 34 | 100 | 14 | 93.33 | 0.306 |
| wv + vv | 1 | 2.04 | 1 | 6.67 | ||||
| rs104886003 (PIK3CA) |
ww | 47 | 95.92 | 33 | 94.29 | 14 | 100 | 1.00 |
| wv + vv | 2 | 4.08 | 2 | 5.71 | ||||
| rs121913279 (PIK3CA) |
ww | 46 | 92 | 32 | 91.43 | 14 | 93.33 | 1.00 |
| wv + vv | 4 | 8 | 3 | 8.57 | 1 | 6.67 | ||
| rs662 (PON1) |
ww | 23 | 46 | 18 | 51.43 | 5 | 33.33 | 0.355 |
| wv + vv | 27 | 54 | 17 | 48.57 | 10 | 66.67 | ||
| rs707557 (RAB22A) |
ww | 21 | 42 | 15 | 42.86 | 6 | 40 | 1.000 |
| wv + vv | 29 | 58 | 20 | 57.14 | 9 | 60 | ||
| rs77679196 (TRPC6) |
ww | 48 | 96 | 34 | 97.14 | 14 | 93.33 | 0.514 |
| wv + vv | 2 | 4 | 1 | 2.86 | 1 | 6.67 | ||
| rs4305714 (chr6 intergenic region) |
ww | 24 | 48.98 | 16 | 47.06 | 8 | 53.33 | 0.762 |
| wv + vv | 25 | 51.02 | 18 | 52.94 | 7 | 46.67 | ||