Table 1.
Characteristics of colorectal cancers (CRCs) classified by stromal periostin (POSTN) expression.
| POSTN | |||||
|---|---|---|---|---|---|
| Total No. | Positive | Negative | p-Value | ||
| 269 (100%) | 119 (44%) | 150 (56%) | |||
| Sex | |||||
| Male | 143 [53%] | 62 [52%] | 81 [54%] | 0.85 a | |
| Female | 126 [47%] | 57 [48%] | 69 [46%] | ||
| Age, years (mean ± S.D.) | 68.6 ± 12.6 | 69.40 ± 12.55 | 67.99 ± 12.67 | 0.36 b | |
| Size, cm (mean ± S.D.) | 5.0 ± 2.6 | 5.22 ± 2.26 | 4.82 ± 2.66 | 0.21 b | |
| Tumor location | |||||
| Right-sided colon | 124 [46%] | 56 [47%] | 68 [45%] | 0.18 a | |
| Left-sided colon | 86 [32%] | 32 [27%] | 54 [36%] | ||
| Rectum | 59 [22%] | 31 [26%] | 28 [19%] | ||
| pT stage | |||||
| pT2 | 36 [13%] | 8 [7%] | 28 [19%] | 0.0098 c | |
| pT3 | 189 [70%] | 88 [74%] | 101 [67%] | ||
| pT4 | 44 [16%] | 23 [19%] | 21 [14%] | ||
| Histological differentiation | |||||
| Well to moderately | 242 [90%] | 105 [88%] | 137 [91%] | 0.53 a | |
| Poorly | 27 [10%] | 14 [12%] | 13 [9%] | ||
| Mucus production | |||||
| Positive | 14 [5%] | 8 [9%] | 6 [3%] | 0.47 a | |
| Negative | 255 [95%] | 111 [91%] | 144 [97%] | ||
| Lymph node metastasis | |||||
| Positive | 124 [49%] | 59 [52%] | 65 [46%] | 0.43 a | |
| Negative | 129 [51%] | 54 [48%] | 75 [54%] | ||
| Peritoneal metastasis | |||||
| Positive | 50 [19%] | 32 [27%] | 18 [12%] | 0.0031 a | |
| Negative | 219 [81%] | 87 [73%] | 132 [88%] | ||
| Distant organ metastasis | |||||
| Positive | 44 [16%] | 30 [25%] | 14 [9%] | <0.001 a | |
| Negative | 225 [84%] | 89 [75%] | 136 [91%] | ||
| Operation status | |||||
| Complete resection | 237 [88%] | 99 [83%] | 138 [92%] | 0.043 a | |
| Incomplete resection | 32 [12%] | 20 [17%] | 12 [8%] | ||
| MMR system status | |||||
| Deficient | 31 [12%] | 13 [11%] | 18 [12%] | 0.94 a | |
| Preserved | 238 [88%] | 106 [89%] | 132 [88%] | ||
ap-values were calculated by the chi-squared test for POSTN expression. bt-test or c Cochran–Armitage trend test was used to calculate p-values. The Bonferroni-corrected p-value for significance was p = 0.0042 (0.05/12).