Table 2.
Clinical responses to CAR-TIL treatment of Dog 4.
| Days after Treatment | Treatment | Number of Cells/kg | CAR Expression | CRP (mg/L) | WBC (109/L) | Eosinophils (109/L) | Side Effects |
|---|---|---|---|---|---|---|---|
| 0 | Dose 1: CAR-TILs | 0.1 million | 79% (mRNA) | <7 | 6.6 | 0.5 | |
| 20 | Dose 2: CAR-TILs | 10 million | 9% (virus) | <7 | 4.4 | 0.3 | |
| 21–24 | IL-2 injections 30,000 IU/kg q12h | Altered appetite, vomiting and diarreha all grade 1 | |||||
| 27–32 | IL-2 injections 30,000 IU/kg q24h | 43 | 12.9 | 2.5 | Eosinophilia, altered appetite, vomiting, diarreha and lethargy all grade 1 | ||
| 34 | 12 | 22.1 | 10.9 | Eosinophilia grade 1 | |||
| 241 | Revisit, in CR | ||||||
| 290 | Revisit, still in CR |