Figure 1.

Role of hedgehog signaling in organogenesis. Hedgehog (HH) signaling is highly conserved across species and plays a major role in organogenesis during the embryonic life. The schematic presentation shows the days in mouse embryonic development (considering the day of mating plug positive as E0.5). Name of the functions and the dotted lines indicate the duration in embryonic days when SHH, IHH, and DHH control the developmental processes. Both IHH and DHH play an important role in the development of gonads, while SHH and IHH contributes to vasculogenesis, gastrointestinal development, and the development of prostate gland.