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The role of hedgehog signaling in ovarian folliculogenesis. DHH and IHH are expressed in granulosa cells (GCs) of activated ovarian follicles. The major role of HH signaling in ovary involves development and differentiation of theca cells (TCs). Loss of both DHH and IHH in GCs leads to lack of TC development of both mesonephros or mesenchyme origin, associated with ineffective steroidogenesis, and infertility due to failure of ovulation.
