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. 2023 Jan 19;15(3):644. doi: 10.3390/cancers15030644

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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RRAS2 mRNA expression is significantly reduced in Ibrutinib-treated CLL patients. (a) Box and whiskers plots showing all points (n = 193), median and mean values of the RRAS2 mRNA relative expression of untreated patients (left column; n = 179) and Ibrutinib-treated patients (right column; n = 14). (b,c) Box and whiskers plots of the total leukocyte and lymphocyte counts respectively, in the blood of untreated (left column) and Ibrutinib-treated (right column) patients. Statistical significance was assessed using a two-tailed unpaired t-test with Welch’s correction. n.s: not significant.