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. 2023 Feb 2;15(3):957. doi: 10.3390/cancers15030957

Figure 5.

Figure 5

FBXO43 promotes proteasomal degradation of p53 via upregulating UBE2C. (A) Volcano plot indicating differentiated gene expression profiles between HCC tissues with low and high FBXO43 expression in TCGA. (B). The KEGG enrichment of differentiated genes between HCC tissues with low and high FBXO43 expression. (C) The expression of UBE2C in HCC tissues with low and high FBXO43. (D) The pearson correlation between FBXO43 and UBE2C expression in HCC tissues. (E) RT-qPCR indicating the expression of FBXO43, UBE2C, and p53 in HepG2 and HCCLM3 cells with FBXO43 depletion. (F) WB results indicating the level of UBE2C and p53 in HepG2 and HCCLM3 cells with FBXO43 depletion. (G) The IP and WB results showing the level of total ubiquitinated p53, p53, and UBE2C in HepG2 and HCCLM3 cells co-transfected with siFBXO43 and UBE2D expression plasmids. ns, no significant difference; ***, p < 0.001.