Figure 1.
Overview of enzymatic reactions catalyzed by amino-acid metabolizing enzymes with known immunosuppressive properties in cancer. ARG1: arginase 1; GLS1: glutaminase 1; IDO1: indoleamine 2,3-dioxygenase 1; IL4I1: interleukin 4 induced 1; iNOS: inducible nitric oxide synthase; NFK: N-formylkynurenine; TDO: tryptophan 2,3-dioxygenase.