Figure 5.

A schematic representation of how pharmacological agents that inhibit CaMKII targeting could be used therapeutically. As CaMKII that is phosphorylated at different sites binds to different binding proteins to produce different functional responses, an inhibitor that specifically blocks the interaction of CaMKII with a particular binding partner will inhibit a specific functional response, while leaving all the other pools of CaMKII bound to other binding proteins, untouched, and able to produce their normal functional response. Coloured oblong shapes represent generic proteins with which CaMKII (purple disc) binds directly or indirectly. Dark grey bar represents a membrane. Geometric protrusions from CaMKII, and indents in the binding proteins represent binding sites for CaMKII. The small red disc represents the phosphorylation of a protein. See text for explanation of the sequence of events shown in the Figure.