Table 1.
Effects on CaMKII activity and targeting following autophosphorylation at threonine (Thr) 253, 286 and 305/306.
| Site of Autophosphorylation |
Effect on CaMKII In Vitro | Effect on Targeting to: | |||
|---|---|---|---|---|---|
| Ca2+/CaM Binding | Ca2+/CaM Dependent Activity | Ca2+/CaM Independent Activity | Translocation to PSD # In Vivo # | Binding to Specific Proteins | |
| Thr286 | ↑ | Prolonged | ↑ | ↑ | Multiple |
| Thr305/306 | ↓ | ↓ | - | ↓ | N/E |
| Thr253 | - | - | - | ↑ | Multiple |
# The post-synaptic density (PSD) is an assemblage of regulatory and cytoskeletal proteins on the cytoplasmic surface of the post-synaptic plasma membrane that regulates synaptic function. - = no effect; N/E = not examined.