Table 2.

Proteins that alter their binding to CaMKII in response to changes in CaMKII phosphorylation.

Binding Partner		Effect of CaMKII Phosphorylation/Phospho-Mimic Mutation on Binding	Ref
Protein	Cellular Function
Brain and acute leukaemia (BAALC) 1-6-8	Haematopoietic cell proliferation, survival, and differentiation	Non-phosphorylated and 286 phospho-mimic mutants bind, 253 phospho-mimic mutation significantly increases binding	[93,96]
Calcium channel α-subunit isoforms (L-type)	Calcium influx	Non-phosphorylated CaMKII binds α1, α2a, α3 and α4 subunits; pThr286 binds only α1 and α2a subunits	[97]
Camguk/CASK	Synaptic targeting and synaptic plasticity	Non-phosphorylated CaMKII binds, pThr305/306 decreases binding	[95]
Densin-180 (LRRC7)	Dendritic scaffolding protein	pThr286 enhances binding compared to non-phosphorylated CaMKII	[98,99]
Desmin	Muscle intermediate filament	Non-phosphorylated CaMKII binds, 286 and 253 phospho-mimic mutations increase binding	[91,92,93]
Diacylglycerol lipase α (DGLα)	Key enzyme in biosynthesis of the endocannabinoid 2-arachidonoylglycerol	Non-phosphorylated CaMKII does not bind, pT286 directly interacts	[100]
Metabotropic glutamate receptor 5 (mGluR5)	Metabotropic glutamate receptor involved in various brain functions, including motor behaviour, memory and cognition	pT286 decreases binding compared to non-phosphorylated CaMKII	[101]
Microtubule-associated protein 2 (MAP-2)	Microtubule assembly	Non-phosphorylated CaMKII binds, 286 phospho-mimic mutation increases binding	[91,92,93]
Myelin Basic Protein (MBP)	Major component of the myelin sheath	Non-phosphorylated CaMKII binds, 286 phospho-mimic mutation slightly decreases binding, 253 phospho-mimic mutation abrogates binding	[93]
GRIN2A/2B (GluN2A/2B)	Subunit of voltage-sensitive ionotropic glutamate receptor involved in synaptic plasticity	pThr286 enhances binding compared to non-phosphorylated CaMKII	[85,86,87,88]
Projectin	Integral protein of insect flight muscle	pThr286 decreases binding compared to non-phosphorylated CaMKII	[102]
Syntaxin 1A	Component of exocytotic molecular machinery	Non-phosphorylated CaMKII did not bind, pT286 directly interacts	[103]
Tau	Microtubule assembly	Non-phosphorylated and 253 phospho-mimic mutation bind, 286 phospho-mimic mutation increases binding	[92,93,104]
Tyrosine hydroxylase isoform 2 (human)	Catecholamine biosynthesis	Non-phosphorylated and 286 phospho-mimic mutants bind, 253 phospho-mimic mutation increases binding	[93]
Tyrosine hydroxylase isoform 2 (human), phosphorylated at Ser19 and Ser40	Catecholamine biosynthesis	Binding is enhanced for non-phosphorylated, 286 and 253 phospho-mimic mutation when compared to non-phosphorylated tyrosine hydroxylase	[93]