Table 1.
Published organ-on-a-chip studies of cancer carried out by UK institutions and companies, demonstrating the breadth of models being developed in oncology.
| Study | Chip System | Chip Material * | Organ/Cancer | Cell Lines/Tissue | Drug Treatment | Mechanical Stimulation |
|---|---|---|---|---|---|---|
| Algarni et al., Bio-Microfluidics 2019 [46] |
µSlide I Luer, Vena8 |
PS, COC |
Ovarian, Brain |
ES-2, U87, HUVECS |
- | Flow |
| Algarni et al., Thromb. Res. 2016 [47] |
Custom | PS | Pancreas, Brain |
ASPC1, U87 |
- | Flow |
| Ayuso et al., Sci. Rep. 2016 [31] |
Custom | PS | Colon, Brain |
HCT-116, U-251 MG, Jurkat |
Doxorubicin | Flow |
| Azimi et al., Sci. Rep. 2020 [54] |
Quasi-vivo | PDMS | Breast | MDA-MB-231, SKBR3 |
Doxorubicin | Flow |
| Bertulli et al., Sci. Rep. 2018 [36] |
Custom | PDMS | Breast | MDA-MB-231, LM2-4175 |
- | - |
| Boussommier-Calleja et al., Biomaterials 2019 [43] |
Custom | PDMS | Breast | MDA-MB-231, MDA-MB-435, HUVECS, Donor monocytes | - | - |
| Cai et al., Adv. Mat. 2019 [44] |
GeminiChip | Glass | Liver epithelial | HepG2 | - | Compression |
| Carr et al., Head Neck Surg. 2014 [58] |
Custom | Glass | Head & Neck | Human Tissue |
Radiation | - |
| Cheah et al., Int. J. Onc. 2017 [57] |
Custom | Glass | Head & Neck | Human Primary Cells | Radiation | - |
| Collins et al., Bio- microfluidics 2021 [39] |
Custom | Glass | Brain, Breast | U87 MG, MCF-7 |
- | Flow |
| Gerigk et al., Lab Chip 2021 [41] |
Custom | PDMS | Brain | U87, Primary, HUVECS |
- | - |
| Hübner et al., Sci. Rep. 2018 [32] |
MOC | PS | Lung | NCI-H292, Skin tissue |
Cetuximab | Flow |
| Kennedy et al., Sci. Rep. 2019 [59] |
Custom | PEEK, sintered disk | Head & Neck | Human Tissue |
Radiation, Cisplatin |
- |
| Kühlbach et al., Bioengineering 2018 [37] |
Custom | PET, PDMS | Lung, Skin | H838, SK-Mel 28, HPAEC | - | Flow |
| Lee et al., Int. Biol. 2020 [40] |
Custom | PDMS | Pancreas | Panc1, hTERT-HPNE |
- | Flow |
| Li et al., Carcin 2017 [42] |
Custom | PDMS | Breast | MDA-MB-231, SKBR-3, BT549, MCF-7, SUM149, MCF-10A, HEK293T |
- | - |
| Mercurio et al., Front Pharmacol. 2019 [45] |
AIM Biotech | PS | Angiogenesis | HUVECS | Thalidomide | - |
| Naumovska et al., Int. J. Mol. Sci. 2020 [60] |
MIMETAS | PS | Colon | Caco-2, hiPSC |
- | Flow |
| Ouattara et al., Mol. Biosyst. 2012 [51] |
Custom | PDMS | Liver epithelial | HepG2/C3a | - | - |
| Petreus et al., Commun. Biol. 2021 [55] |
Ibidi | PS | Colorectal | SW620 | Irinotecan (SN38) |
- |
| Riley et al., BMC Cancer 2019 [56] |
Custom | PEEK, sintered disk | Thyroid | Human Tissue |
- | - |
| Singh et al., PLOS Biol. 2022 [34] |
Custom | PDMS | Pharyngeal, Lung | FaDu, Calu-6, A549 | - | - |
| Choucha Snouber et al., Toxic Sci. 2013 [52] |
Custom | PDMS | Liver epithelial | HepG2/C3a | Flutamide | - |
| Verbruggen et al., Cancers 2021 [38] |
Emulate | PDMS | Breast, Prostate, Bone | MDA-MB-231, PC3, MLO-Y4 | - | Flow |
| Virumbrales-Muñoz et al., Sci. Rep. 2017 [50] |
Custom | SU-8 | Breast | MDA-MB-231, HUVECS | TRAIL | - |
| Wang et al., Theranostics 2020 [53] |
Custom | PDMS | Kidney, Liver |
Caki-1, HepLL |
5-Fluorouracil | - |
| Wei et al., Talanta 2021 [33] |
Custom | PDMS | Cervical, Lung |
HeLa, A549 |
- | - |
Abbreviations: PS = polystyrene; COC = cyclo olefin copolymer; PDMS = polydimethylsiloxane; PEEK = polyether ether ketone; PET = polyethylene terephthalate; TRAIL = TNF-related apoptosis inducing ligand.