Table 2.
Patient characteristics of Swedish early-onset colorectal cancer* (2007–2016), separated for concomitant comorbid conditions.
| No Comorbid Conditions (n = 1465) n (%) |
Autoimmune Disease without IBD or Metabolic (n = 47) n (%) |
Metabolic Disease without IBD (n = 956) n (%) |
IBD without Metabolic Disease (n = 97) n (%) |
IBD with Metabolic Disease (n = 61) n (%) |
Total (n = 2626) n (%) |
|
|---|---|---|---|---|---|---|
| Age | ||||||
| Median, years [min, max] |
43.0 (19.0, 49.0) |
44.0 (27.0, 49.0) |
45.0 (21.0, 49.0) |
38.0 (21.0, 49.0) |
42.0 (30.0, 49.0) |
44.0 (19.0, 49.0) |
| Weight | ||||||
| Mean, kg (SD) | 75.1 (16.1) | 79.3 (17.2) | 81.9 (18.3) | 74.4 (14.6) | 91.3 (22.0) | 77.9 (17.5) |
| Missing | 275 (18.8) | 9 (19.1) | 221 (23.1) | 14 (14.4) | 8 (13.1) | 527 (20.1) |
| Height | ||||||
| Mean, cm (SD) | 174 (9.8) | 175 (11.6) | 174 (9.8) | 176 (7.4) | 177 (8.2) | 174 (9.7) |
| Missing | 304 (20.8) | 9 (19.1) | 243 (25.4) | 17 (17.5) | 9 (14.8) | 582 (22.2) |
| BMI | ||||||
| Mean, kg/m2 (SD) | 24.8 (4.3) | 25.9 (4.5) | 27.1 (5.2) | 24.0 (4.1) | 29.0 (7.0) | 25.7 (4.9) |
| Missing | 309 (21.1) | 9 (19.1) | 245 (25.6) | 17 (17.5) | 9 (14.8) | 589 (22.4) |
| Sex | ||||||
| Male | 763 (52.1) | 21 (44.7) | 508 (53.1) | 73 (75.3) | 46 (75.4) | 1411 (53.7) |
| Female | 702 (47.9) | 26 (55.3) | 448 (46.9) | 24 (24.7) | 15 (24.6) | 1215 (46.3) |
|
Duration
of education |
||||||
| <9 years | 150 (10.2) | 2 (4.3) | 126 (13.2) | 14 (14.4) | 6 (9.8) | 298 (11.3) |
| 10–12 years | 717 (48.9) | 26 (55.3) | 512 (53.6) | 46 (47.4) | 30 (49.2) | 1331 (50.7) |
| 12> years | 589 (40.2) | 19 (40.4) | 304 (31.8) | 36 (37.1) | 25 (41.0) | 973 (37.1) |
| Missing | 9 (0.6) | - | 14 (1.5) | 1 (1.0) | - | 24 (0.9) |
| Income group | ||||||
| Lower quartile | 352 (24.0) | 13 (27.7) | 223 (23.3) | 35 (36.1) | 18 (29.5) | 641 (24.4) |
| Middle two quartiles | 744 (50.8) | 21 (44.7) | 498 (52.1) | 41 (42.3) | 35 (57.4) | 1339 (51.0) |
| Upper quartile | 362 (24.7) | 13 (27.7) | 234 (24.5) | 21 (21.6) | 7 (11.5) | 637 (24.3) |
| Missing | 7 (0.5) | - | 1 (0.1) | - | 1 (1.6) | 9 (0.3) |
| ASA Class | ||||||
| 1 | 729 (49.8) | 13 (27.7) | 314 (32.8) | 21 (21.6) | 9 (14.8) | 1086 (41.4) |
| 2 | 443 (30.2) | 22 (46.8) | 371 (38.8) | 56 (57.7) | 28 (45.9) | 920 (35.0) |
| 3 | 71 (4.8) | 4 (8.5) | 95 (9.9) | 7 (7.2) | 16 (26.2) | 193 (7.3) |
| 4 | 8 (0.5) | - | <5 | <5 | - | 12 (0.5) |
| Missing | 214 (14.6) | 8 (17.0) | 173 (18.1) | 12 (12.4) | 8 (13.1) | 415 (15.8) |
| Cancer location | ||||||
| Right-side colon cancer |
402 (27.4) | 14 (29.8) | 251 (26.3) | 37 (38.1) | 31 (50.8) | 735 (28.0) |
| Left-side colon cancer |
490 (33.4) | 18 (38.3) | 327 (34.2) | 28 (28.9) | 17 (27.9) | 880 (33.5) |
| Rectal cancer | 569 (38.8) | 15 (31.9) | 372 (38.9) | 32 (33.0) | 12 (19.7) | 1000 (38.1) |
| Missing | 4 (0.3) | - | 6 (0.6) | - | 1 (1.6) | 11 (0.4) |
| Tumor stage | ||||||
| I | 220 (15.0) | 9 (19.1) | 117 (12.3) | 17 (17.5) | 10 (16.4) | 373 (14.2) |
| II | 334 (22.8) | 13 (27.7) | 170 (17.8) | 15 (15.5) | 17 (27.9) | 549 (20.9) |
| III | 442 (30.2) | 12 (25.5) | 273 (28.6) | 36 (37.1) | 19 (31.1) | 782 (29.8) |
| IV | 428 (29.2) | 10 (21.3) | 360 (37.7) | 25 (25.8) | 12 (19.7) | 835 (31.8) |
| Missing | 41 (2.8) | 3 (6.4) | 36 (3.8) | 4 (4.1) | 3 (4.9) | 87 (3.3) |
| Metabolic disease | ||||||
| Type 2 diabetes | - | - | 178 (18.6) | - | 11 (18.0) | 189 (7.2) |
| Hypertension | - | - | 807 (84.4) | - | 47 (77.0) | 854 (32.5) |
| Lipidemia | - | - | 254 (26.6) | - | 27 (44.3) | 281 (10.7) |
| Obesity | - | - | 35 (3.7) | - | 6 (9.8) | 11 (0.4) |
| Fatty liver | - | - | <5 | - | <5 | <5 |
| Two or more of the above |
- | - | 238 (24.9) | - | 19 (31.1) | 257 (9.8) |
| IBD condition | ||||||
| Ulcerative colitis | - | - | - | 46 (47.4) | 28 (45.9) | 74 (2.8) |
| Crohn’s disease | - | - | - | 19 (19.6) | 13 (21.3) | 32 (1.2) |
| IBD-unclassified | - | - | - | 32 (33.0) | 20 (32.8) | 52 (2.0) |
* Age < 50 years at diagnosis. Abbreviations: CRC, colorectal cancer; SD, standard deviation; BMI, body mass index; IBD, inflammatory bowel disease; ASA, American Society of Anesthesiologists.