Table 3.
Conditional logistic regression models of the incidence of early-onset colorectal cancer conditioning on matched risk set, with covariates: indicators for non-IBD autoimmune disease, metabolic disease, IBD, and an interaction term between metabolic disease and IBD.
| Comparison | Cases (Yes/No) | Controls (Yes/No) | Main Effect Model HR (95% CI) | Interaction Model HR (95% CI) |
|---|---|---|---|---|
| Non-IBD autoimmune disease | 172/2454 | 816/14,940 | 1.28 (1.08–1.52) | 0.97 (0.81–1.16) |
| Metabolic disease | 1017/1609 | 4163/11,593 | 1.82 (1.67–1.99) | - |
| without IBD | 956/1512 | 4092/11,495 | - | 1.82 (1.66–2.00) |
| IBD | 158/2468 | 169/15,587 | 5.98 (4.78–7.48) | - |
| with metabolic disease | 61 | 71 | - | 3.65 (2.57–5.19) |
| without metabolic disease | 97 | 98 | - | 7.52 (5.62–10.06) |
Abbreviations: IBD, inflammatory bowel disease; HR, hazard ratio; CI, confidence interval.