Table 2.

Frequently reported dose-limiting toxicities associated with payload classes.

	Approved/Late-Stage ADCs	Linker Type	Key Toxicities
Tubulin inhibitors
MMAE	Brentuximab Vedotin, Polatuzumab Vedotin, Enfortumab Vedotin, Tisotumab Vedotin, Disitamab Vedotin	Cleavable	Neutropenia, peripheral neuropathy, anemia, skin toxicity
MMAF	Belantamab Mafodotin	Non-cleavable	Thrombocytopenia, ocular toxicity, hepatic toxicity
DM1	Trastuzumab Emtansine	Non-cleavable	Thrombocytopenia, hepatic toxicity
DM4	Mirvetuximab Soravtansine	Cleavable	Neutropenia, anemia, peripheral neuropathy, ocular toxicity
DNA-crosslinkers/ DNA-alkylators
Calicheamicin	Gemtuzumab Ozogamicin, Inotuzumab Ozogamicin	Cleavable	Neutropenia, thrombocytopenia, hepatic toxicity
PBD	Loncastuximab Tesirine	Cleavable	Neutropenia, thrombocytopenia, anemia, serosal effusion, nephron toxicity, skin toxicity
Duocarmycin	Trastuzumab Duocarmazine	Cleavable	Neutropenia, thrombocytopenia, serosal effusion
Topoisomerase inhibitors
SN-38	Sacituzumab Govitecan	Cleavable	Neutropenia, gastrointestinal toxicity
Deruxtecan	Trastuzumab Deruxtecan	Cleavable	Neutropenia, gastrointestinal toxicity