Table 2.

Univariate and multivariate Cox regression analyses of the OS in each TNBC subtype.

	Univariate Analysis			Multivariate Analysis
Variables	HR	95% CI	p-Value	HR	95% CI	p-Value
BL1-subtype
BL1-TSPSig (high vs. low)	2.716	1.258–5.865	0.011 *	2.692	1.171–6.188	0.020 *
Chemotherapy (yes vs. no)	1.027	0.524–2.010	0.939	1.567	0.643–3.819	0.323
Age	1.021	0.994–1.049	0.126	1.018	0.984–1.053	0.302
Tumor_size	1.031	1.006–1.056	0.014 *	1.031	0.999–1.064	0.062 .
Stage (III vs. I/II)	1.310	0.314–5.472	0.711	0.597	0.107–3.342	0.557
BL2-subtype
BL2-TSPSig (high vs. low)	2.006	0.656–6.139	0.222	1.330	0.208–8.525	0.763
Chemotherapy (yes vs. no)	0.609	0.241–1.539	0.295	0.455	0.123–1.682	0.238
Age	1.035	1.000–1.074	0.067 .	1.028	0.981–1.077	0.247
Tumor_size	1.023	1.003–1.045	0.025 *	1.017	0.989–1.045	0.237
Stage (III vs. I/II)	3.400	1.320–8.759	0.011 *	3.293	1.075–10.093	0.037 *
LAR-subtype
LAR-TSPSig (high vs. low)	2.361	1.129–4.938	0.023 *	2.369	1.100–5.105	0.028 *
Chemotherapy (yes vs. no)	1.396	0.680–2.863	0.364	1.404	0.561–3.515	0.468
Age	1.015	0.982–1.050	0.376	1.008	0.968–1.051	0.694
Tumor_size	1.023	1.007–1.039	0.006 **	1.021	1.004–1.039	0.018 *
Stage (III vs. I/II)	2.130	0.805–5.627	0.128	1.049	0.335–3.283	0.934
M-subtype
M-TSPSig (high vs. low)	0.497	0.147–1.674	0.259	0.501	0.143–1.759	0.281
Chemotherapy (yes vs. no)	1.195	0.515–2.775	0.678	1.283	0.372–4.424	0.693
Age	0.991	0.957–1.027	0.624	1.001	0.954–1.050	0.970
Tumor_size	1.025	1.000–1.051	0.046 *	1.028	1.002–1.055	0.035 *
Stage (III vs. I/II)	10.38	2.079–51.830	0.004 **	9.161	1.558–53.863	0.014 *

TSPSig, the TNBC subtype-specific prognosis signature; **, p < 0.01; *, 0.01 ≤ p < 0.05; ., 0.05 ≤ p < 0.1.