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. 2023 Jan 29;15(3):819. doi: 10.3390/cancers15030819

Figure 2.

Figure 2

DHEA diminishes oxygen consumption rate and extracellular acidification rate in MDA-MB-231 and MDA-MB-436 breast cancer cells. The Seahorse XF96 analyzer was employed to determine the mitochondrial and glycolytic profile of MDA-MB-231 and MDA-MB-436 breast cancer cells treated with DHEA 10 μM for 24 h. (A) OCR profile. (B) Respiration (basal and maximal), as well as ATP levels, Proton Leak, and Spare respiratory capacity. (C) ECAR profile. (D) Glycolysis, Glycolytic Reserve, and Glycolytic Reserve Capacity. The values represent the mean ± SEM of three different experiments. * p < 0.01, ** p < 0.001, **** p < 0.00001, ns = not significant.