Table 1.
Proposed diagnostic criteria for thrombotic microangiopathy.
| Criteria | BMT-CTN, 2005 | IWG, 2007 | Jodele, 2014 |
|---|---|---|---|
| Parameter | All Criteria Present | All Criteria Present | ≥4 of 7 Criteria Present in ≥2 Occasions in 14 Days |
| Anemia or increasing RBC transfusion requirements | YES | YES | YES |
| New-onset thrombocytopenia, >50% decrease in PLT count, increase in PLT transfusion requirements | YES | YES | YES |
| Presence of schistocytes | YES (≥2 per HPF) | YES (>4%) | YES |
| Elevated LDH | YES | YES | YES |
| Decreased haptoglobin | ----- | YES | ----- |
| Hypertension | ----- | ----- | YES |
| Proteinuria | ----- | ----- | YES |
| Elevated sC5b-9 | ----- | ----- | YES |
| Renal dysfunction | YES | ----- | ----- |
The presence of end-organ damage is a marker of severity; renal biopsy is not required for diagnosis, but if obtained, it is then sufficient for the establishment of diagnosis.