Table 3.
Biomarkers associated with endothelial dysfunction related post-transplant syndromes.
| Marker | VOD/SOS | TAM | IPS/DAH | GVHD |
|---|---|---|---|---|
| Coagulation factors | ||||
| VWF | ↑ | ↑ | ----- | ↑ |
| TM | ↑ | ↑ | ----- | ↑ |
| PAI1 | ↑ | ----- | ----- | ----- |
| Cell adhesion molecules | ||||
| ICAM | ↑ | ----- | ↑ | ↑ |
| VCAM | ----- | ↑ | ↑ | ----- |
| E-selectin | ↑ | ↑ | ----- | ↑ |
| P-selectin | ↑ | ----- | ----- | ----- |
| Proinflammatory cytokines | ||||
| TNFa | ↑ | ----- | ↑ | ↑ |
| IL6 | ----- | ----- | ----- | ↑ |
| sIL2R | ↑ | ----- | ----- | ↑ |
| Angiogenetic factors | ||||
| CEC | ----- | ----- | ----- | ↑ |
| VEGF | ↑ | ----- | ----- | ----- |
| Ang2 | ----- | ----- | ↑ | ↑ |
| Panels | ||||
| EASIX | ↑ | ↑ | ----- | ↑ |
| MAGIC (ST2, REG3a) | ----- | ----- | ----- | ↑ |
TM, thrombomodulin; PAI1, plasminogen activator inhibitor-1; ICAM, intercellular adhesion molecule; VCAM, vascular cell adhesion molecule; TNFa, tumor necrosis factor; IL6, interleukin-6; sIL2R, soluble IL2 receptor; CEC, circulating endothelial cells; VEGF, vascular endothelial growth factor; Ang2, angiopoetin-2; EASIX, endothelial activation and stress index; ST2, suppression of tumorigenicity 2; REG3A, regenerating islet-derived 3-alpha.