Table 2.
LGG models.
| Model Category | Specific Model | Genes Involved | Genetic Heterogeneity |
Immunocompetent | Brain Micro-Environment | Blood–Brain Barrier | Reproducible |
|---|---|---|---|---|---|---|---|
| Murine cell line | ENU-induced murine tumor cells | BRAF, TP53, PDGFRa, CDKN2a, EGFR, and no IDH | yes | no | no | no | no |
| Murine cell line | IDH1 mutant expression in SVC cells | IDH | no | no | no | no | yes |
| Patient-derived cell line | BT142 | IDH | no | no | no | no | yes |
| Patient-derived cell line | TS603 | IDH, 1p/19q codeletion | no | no | no | no | yes |
| Murine-derived GEMMs | Sleeping Beauty transposase system | IDH, TP53, and ATRX | no | yes | yes | yes | yes |
| Murine-derived GEMMs | RCAS-mutIDH-PDGFA-CDKN2A-ATRX-PTEN | IDH, CDKN2a, ATRX, PTEN, and PDGFA | no | yes | yes | yes | yes |
| Murine derived GEMMs | RCAS-mutIDH-PDGF driven-p53 knockdown | IDH, PDGF, and TP53 | no | yes | yes | yes | yes |
| Patient-derived murine model | Various LGG orthotopic xenografts | IDH, FUBP1, and CIC | partially | no | partially | yes | yes |
| Genetically modified neurosphere | hESCs with lentiviral modification | IDH, TP53, and ATRX | no | no | no | no | yes |
| Mouse to mouse xenograft | PDGF-B overexpressing mouse NSC into mouse brain | PDGF-B | partially | yes | yes | yes | yes |
| iPSC | human LGG iPSC | IDH | partially | no | no | no | yes |