Table 1.
General toxicity data of male rats subcutaneously treated with different doses of estradiol valerate plus cyproterone acetate five times a week, for 2 weeks: CM 0—sesame oil, D1M 0.09 + 0.33, D2M 0.09 + 0.93 and D3M 0.18 + 0.33 mg. Statistical significance: * p < 0.05 Mann–Whitney test. n: number; SD: standard deviation.
| CM | D1M | D2M | D3M | |
|---|---|---|---|---|
| n | 4 | 4 | 4 | 4 |
| Feed consumption (g, mean ± SD) |
21.04 ± 0.08 | 13.48 ± 0.40 * | 15.69 ± 0.77 * | 14.97 ± 1.22 * |
| Testis absolute weight (g, mean ± SD) |
3.49 ± 0.15 | 2.20 ± 0.50 * | 2.16 ± 0.16 * | 2.21 ± 0.21 * |
| Testis relative weight (mean ± SD) |
1.05 ± 0.06 | 0.86 ± 0.22 | 0.83 ± 0.07 * | 0.86 ± 0.07 * |
| Liver absolute weight (g, mean ± SD) |
12.23 ± 1.17 | 10.03 ± 1.50 | 11.20 ± 0.96 | 10.14 ± 0.66 * |
| Liver relative weight (mean ± SD) |
3.65 ± 0.26 | 3.91 ± 0.37 | 4.33 ± 0.24 * | 3.97 ± 0.24 |