Table 2.
General toxicity data of female rats subcutaneously treated with different doses of testosterone enanthate two times a week, for 2 weeks: CF 0—sesame oil; D1F 0.45, D2F 0.95 and D3F 2.05 mg. Statistical significance: § p < 0.05 Fisher exact test; # p < 0.05 linear trend; * p < 0.05 Mann–Whitney test. n: number. SD: standard deviation.
| CF | D1F | D2F | D3F | |
|---|---|---|---|---|
| n | 4 | 4 | 4 | 4 |
| Feed consumption (g, mean ± SD) |
15.8 ± 0.2 | 16.8 ± 1.0 | 15.4 ± 0.5 | 17.9 ± 1.4 * |
| Haemorrhagic ovaries and uteri | 0/4 (0%) # | 0/4 (0%) | 1/4 (20%) | 4/4 (100%) § |
| Clitoral gain (mm, mean ± SD) |
−0.12 ± 0.47 | 0.48 ± 0.43 | 0.24 ± 0.20 | 0.39 ± 0.36 |
| Ovary absolute weight (g, mean ± SD) |
0.17 ± 0.02 | 0.14 ± 0.12 | 0.12 ± 0.02 * | 0.10 ± 0.01 * |
| Ovary relative weight (mean ± SD) |
0.08 ± 0.01 | 0.07 ± 0.01 | 0.06 ± 0.01 * | 0.05 ± 0.01 * |
| Uterus absolute weight (g, mean ± SD) |
0.52 ± 0.07 | 0.36 ± 0.02 * | 0.37 ± 0.03 * | 0.41 ± 0.10 |
| Uterus relative weight (mean ± SD) |
0.21 ± 0.04 | 0.17 ± 0.01 | 0.17 ± 0.02 | 0.18 ± 0.05 |
| Liver absolute weight (g, mean ± SD) |
6.94 ± 0.14 | 7.36 ± 0.59 | 7.47 ±0.61 | 7.25 ± 1.45 |
| Liver relative weight (mean ± SD) |
3.25 ± 0.07 | 3.37 ± 0.25 | 3.48 ± 0.20 | 3.16 ± 0.63 |