. 2023 Feb 1;12(3):474. doi: 10.3390/cells12030474

Table 3.

Histopathological endpoints in target organs of male rats subcutaneously treated with different doses of estradiol valerate plus cyproterone acetate, five times a week, for 2 weeks: CM 0—sesame oil, D1M 0.09 + 0.33, D2M 0.09 + 0.93; and D3M 0.18 + 0.33 mg. Statistical significance: ^§ p < 0.05 Fisher exact test; * p < 0.05 Mann–Whitney test. n: number; SD: standard deviation.

ORGAN/Observation		CM	D1M	D2M	D3M
	N	4	4	4	4
TESTIS: tubule degeneration with germinal epithelium degeneration
	0	4
	2		4
	3			4
	4				4
	Total Finding Incidence	0	4 ^§	4 ^§	4 ^§
TESTIS: tuble area (μm²; mean ± SD)		422.3 ± 74.3	271.9 ± 147.1	264.8 ± 85.8	223.0 ± 30.7 *
LIVER: sinusoidal dilatation
	0	4
	1		2
	2		2	4	4
	Total Finding Incidence	0	4 ^§	4 ^§	4 ^§
LIVER: hepatocyte vacuolation
	0	4
	1		4
	2			2
	3			2	4
	Total Finding Incidence	0	4 ^§	4 ^§	4 ^§