Table 4.
Histopathological endpoints in target organs of female rats subcutaneously treated with different doses of testosterone enanthate two times a week, for 2 weeks: CF 0—sesame oil, D1F 0.45, D2F 0.95 and D3F 2.05 mg. Statistical significance: § p < 0.05 Fisher exact test; ## p < 0.01 linear trend; * p < 0.05 Mann–Whitney test. n: number. SD: standard deviation.
| ORGAN/Observation | CF | D1F | D2F | D3F | |
|---|---|---|---|---|---|
| N | 4 | 4 | 4 | 4 | |
| UTERUS: endometrial and/or myometrial hyperaemic vessels | |||||
| 0 | 4 | 4 | 3 | ||
| 3 | 1 | 4 | |||
| Total Finding Incidence | 0 ## | 0 | 1 | 4 § | |
| UTERUS: total horn areas (μm2; mean ± SD) | 60,651 ± 12,149 | 33,878 ± 3137 * | 36,023 ± 8422 * | 37,795 ± 11,903 | |
| UTERUS: lumen areas (μm2; mean ± SD) | 3864 ± 3878 | 1355 ± 514 | 1683 ± 1364 | 1032 ± 248 * | |
| UTERUS: myometrium areas (μm2; mean ± SD) | 12,614 ± 1158 | 7660 ± 1396 * | 7269 ± 2350 * | 9464 ± 2730 | |
| UTERUS: endometrium areas (μm2; mean ± SD) | 26,246 ± 3253 | 17,261 ± 1939 * | 17,495 ± 3596 * | 13,519 ± 5230 * | |
| UTERUS: endometrium/myometrium areas (mean ± SD) | 2.09 ± 0.28 | 2.31 ± 0.52 * | 2.52 ± 0.60 * | 1.44 ± 0.33 * | |
| UTERUS: luminal epithelium height (μm; mean ± SD) | 23.03 ± 1.56 | 18.10 ± 3.80 | 17.14 ± 2.23 * | 17.60 ± 1.98 * | |
| OVARY: hyperaemic vessels | |||||
| 0 | 4 | 4 | 2 | ||
| 2 | 2 | 4 | |||
| Total Finding Incidence | 0 ## | 0 | 2 | 4§ | |
| OVARY: follicular density (mean ± SD) | 0.08 ± 0.0 | 0.11 ± 0.1 | 0.14 ± 0.0 | 0.15 ± 0.0 | |
| OVARY: primary + secondary follicles (n; mean ± SD) | 28.5 ± 11.7 | 21.25 ±10.5 | 47.3 ±14.2 | 65 ± 6.8 * | |
| OVARY: Graaf follicles (n; mean ± SD) | 3.5 ±1.3 | 2.5 ± 1.0 | 2.5 ± 1.0 | 1.25 ± 0.5 * | |
| LIVER: hepatocyte vacuolation | |||||
| 0 | 4 | 4 | |||
| 1 | 4 | 4 | |||
| Total Finding Incidence | 4 | 4 | 0 § | 0 § | |
| LIVER: sinusoidal dilatation | |||||
| 0 | 4 | ||||
| 1 | 4 | ||||
| 2 | 3 | ||||
| 3 | 1 | 4 | |||
| Total Finding Incidence | 0 | 4 § | 4 § | 4 § | |