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. 2023 Jan 19;15(3):632. doi: 10.3390/cancers15030632

Figure 1.

Figure 1

Overexpression of angiotensin-converting enzyme 2 (ACE2) confers the permissiveness of A549 cells to SARS-CoV-2. Naïve A549 (a–c) or Huh7.5 (d–f) cells or cells transduced by lentiviruses encoding ACE2 alone or together with TMPRSS2 were infected with SARS-CoV-2 and harvested 4 days post-infection (d.p.i.). Levels of ACE2 (a,d), TMPRSS2 (b,e) mRNA or SARS-CoV-2 RNA (c,f) were assessed by reverse transcription with real-time polymerase chain reaction (RT-qPCR). The levels were normalized to the levels of mRNA of β-glucoronidase (GUS). The values represent the means ± standard deviation (S.D.). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.