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Effects of PD-1 expression and blocking on ILC2s. IL-33-activated ILC2s up-regulate PD-1 in order to limit proliferation and cytokine secretion (A). In the melanoma TME, PD-1 blocking by monoclonal antibodies counteracts such restraint, allowing ILC2s to proliferate and produce the cytokines promoting eosinophils infiltration (B).
