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Immunomodulatory properties of BRAF/MEK inhibitors affecting ILC2s. BRAF/MEK inhibitors limit tumor infiltration of MDSCs and Tregs, which may dampen ILC activation through cell–cell contact and suppressive cytokines, such as TGF-β and IL-10 (A, B). Moreover, targeted therapy directly down-regulates IL-10 secretion by melanoma cells (C). Altogether, these phenomena would contribute to the ILC2-mediated infiltration of anti-melanoma eosinophils (D).
