Table 1.

Helper ILCs in melanoma. The table summarizes the current knowledge about the role of the different helper ILC subpopulations in melanoma and how they are affected by ICIs.

Helper ILC Subset	Role in Melanoma	CTLA-4 Function	ICI Effect on CTLA-4	PD-1 Function	ICI Effect on CTLA-4	References
ILC1	Pro-tumoral	Putative exhaustion marker	Putative reversal of activation	Unknown	Untested	[23,24,25,26,34,40,42,43]
ILC2	Anti-tumoral	Putative exhaustion marker	Putative reversal of activation	Inhibition of activation	Reactivation of proliferation and secretory activity	[23,24,25,26,40,49,50,51,52,53,66,67,68,69,70,71,72]
ILC3	Anti-tumoral	Putative exhaustion marker	Putative reversal of activation	Inhibition of activation	Putative reactivation	[23,24,25,26,40,60,61,62,73,74]