Figure 2.

Schematic linear sequence of the calnexin gene and its encoded protein. The human calnexin gene is located on a forward strand of distal end of the long arm of chromosome 5 and is comprised of 15 exons (of which 14 are protein-coding exons) transcribed to a mature transcript of 4915 bp that is translated into a 592 amino acid residue polypeptide. Linear schematic representation of the calnexin protein and the corresponding exons encoding the specific protein domains of calnexin. The white boxes in the gene schematic diagram correspond to the untranslated regions of the first and last exons. The calnexin protein schematic diagram shows the signal peptide (red), the luminal domain (green for the N-domain and blue for the P-domain), the transmembrane domain (TM, yellow) and the cytosolic C-terminal domain (orange). The hatched box represents a portion of the ER membrane. Four repeats of Motif 1 and four repeats of Motif 2 are labelled as “11112222” and depict the proline-rich amino acid sequence repeats in the P-domain. The ER retention signal (RKPRRE) is shown as the most distal C-terminal amino acid sequence.