PLC	primary liver cancer
HCC	hepatocellular carcinoma
ICC	intrahepatic cholangiocarcinoma
CCA	cholangiocarcinoma
HBV	hepatitis B virus
HCV	hepatitis C virus
NAFLD	non-alcoholic fatty liver disease
US-FDA	the United States Food and Drug Administration
HFD	High-fat diet
DEN	Diethylnitrosamine
TG	triglyceride
NASH	nonalcoholic steatohepatitis
HFD	high-fat diet
WD	western-style diet
PD1	programmed death-1
CCl4	carbon tetrachloride
STZ	streptozotocin
KEGG	Kyoto Encyclopedia of Genes and Genomes
MTDH	metadherin
ES	embryonic stem
HDTVi	hydrodynamic tail vein injection
PTEN	phosphatase and tensin homolog
KO	Knockout
SB	sleeping beauty
HDKO	hepatocyte-specific Traf3/Pten double knockout
CDKO	cholangiocyte-specific Traf3/Pten double knockout
JNK	c-Jun N-terminal kinase
TME	tumor microenvironment
CNV	copy number variation
TFs	transcription factors
YAP	Yes-associated protein
CSC	cancer stem cell
CAF	cancer-associated fibroblast
ECM	extracellular matrix
HSC	hepatic stellate cells
TCGA	The Cancer Genome Atlas
PDXs	Patient-derived tumor xenografts
TAMs	tumor-associated macrophages
PR	primary resistance
NPCs	non-parenchymal cells
DHMEQ	Dehydroxymethylepoxyquinomicin
MDSC	myeloid-derived suppressor cells