Table 1.
Associations between CKD and eGFR at baseline with new-onset HUA.
| N | No of Events (%) | Model 1 | Model 2 | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | |||
| CKD at Baseline | ||||||
| Non-CKD | 24,684 | 1502 (6.08%) | 1.00 | 1.00 | ||
| CKD | 749 | 95 (12.68%) | 1.94 (1.58–2.39) | <0.001 | 1.58 (1.28–1.95) | <0.001 |
| Groups of eGFR | ||||||
| (mL·min−1·1.73 m−2) | ||||||
| Group1 (<60) | 135 | 35 (25.93%) | 3.88 (2.77–5.43) | <0.001 | 3.56 (2.50–5.05) | <0.001 |
| Group2 (60~<90) | 3689 | 438 (11.87%) | 1.72 (1.53–1.92) | <0.001 | 1.61 (1.42–1.83) | <0.001 |
| Group3 (90~<120) | 19,191 | 999 (5.21%) | 1.00 | 1.00 | ||
| Group4 (≥120) | 2418 | 125 (5.17%) | 1.74 (1.44–2.10) | <0.001 | 1.74 (1.42–2.14) | <0.001 |
Model 1 was not adjusted for any covariates. Model 2 was adjusted for age (<45 years, 45–64 years, ≥65 years), gender (male, female), BMI (<24.0 kg·m−2, 24.0–27.9 kg·m−2, ≥28 kg·m−2), education (junior high school or below, high school, junior college, bachelor’s degree or above), smoking status (non-smoker, smoker, ex-smoker), drinking status (non-drinker, drinker, ex-drinker), hypertension (no, yes), TC (≤4.20 mmol/L, 4.21–2.00 mmol/L, ≥5.01 mmol/L) at baseline. CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; HUA, hyperuricemia; HR, hazard ratio; CI, confidence interval.