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. 2023 Feb 1;12(3):471. doi: 10.3390/cells12030471

Figure 1.

Figure 1

Structural changes of SGC in response to NO-dependent activation. (A): Schematic representation of the process of NO:-SGC adduct formation. The five-coordinate heme moiety of SGC (state a) binds NO to form a six-coordinate complex (state b). The six-coordinate complex subsequently converts irreversibly into a five-coordinate complex (state c) due to the rupture of Fe-His105 bond. Corresponding reaction rates are indicated. (B): Structural rearrangement of different SGC domains that occurs following NO binding causes significant activation of cGMP-forming activity.