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. 2023 Feb 2;12(3):481. doi: 10.3390/cells12030481

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The prostate cancer xenograft tumor showed suppressed proliferation and enhanced apoptosis after FUS + RT compared to single RT. (A) Representative immunohistochemistry staining and (C) quantification of Ki67 demonstrated that the tumor proliferation was inhibited after a combination treatment of FUS and RT. (B) Fluorescence microscopy images of the TUNEL assay and (D) quantified fluorescence surface area show tumor apoptosis after treatment (green: apoptosis; blue: nucleus). N = 4 (*** p ≤ 0.001).