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Photomicrographs of immunohistochemical staining for HIF-1-α in OSCC tumor samples: (a) SCC of the oral tongue infiltrating the underlying stroma with tumor islands exhibiting central areas of intensive HIF-1-α immunostaining (magnification ×100), (b) SCC of the oral tongue showing tumor islands with central zones of HIF-1-α immunoreactivity in the nuclear and cytoplasmic compartments of the tumor cells (magnification ×400).
