Table 6.
IC50 values of inhibitory effects of orlistat, captopril, acarbose, valerenic acid derivatives and phenolic acids against pancreatic lipase, angiotensin converting enzyme, α-amylase, and α-glucosidase.
| IC50 (mg/mL) 1 | ||||
|---|---|---|---|---|
| Pancreatic Lipase | ACE 2 | α-Amylase | α-Glucosidase | |
| Orlistat | (9.648 ± 0.032) × 10−6E | |||
| Captopril | (0.498 ± 0.014) × 10−6F | |||
| Acarbose | (5.404 ± 0.147) × 10−3E | (9.547 ± 0.003) × 10−2G | ||
| Valerenic acid | nd 3 | 0.225 ± 0.023D | nd | 0.617 ± 0.028F |
| Acetoxyvalerenic acid | nd | nd | nd | 1.827 ± 0.005D |
| Gallic acid | 0.623 ± 0.002D 4 | 2.100 ± 0.028C | 1.258 ± 0.001D | 2.164 ± 0.026C |
| Protocatechuic acid | 0.673 ± 0.009C | 2.462 ± 0.020B | 1.295 ± <0.001C | 3.721 ± 0.042B |
| Chlorogenic acid | 1.108 ± 0.002A | 4.803 ± 0.004A | 1.792 ± 0.003A | 5.524 ± 0.074A |
| Caffeic acid | 0.726 ± 0.003B | 0.094 ± 0.006E | 1.610 ± 0.006B | 1.289 ± 0.024E |
1 IC50 value: the enzyme activity was inhibited by 50%. The IC50 value was obtained by interpolation from linear regression analysis. 2 ACE: Angiotensin converting enzyme. 3 nd = not detected. 4 Each value is expressed as mean ± standard deviation (n = 4). Mean with different capital letters within a column differ significantly (p < 0.05).