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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Curr Opin Physiol. 2022 Jun 3;28:100556. doi: 10.1016/j.cophys.2022.100556

Figure. Summary of the signaling pathways and transcriptional regulation of fibroblast activation.

Figure.

Arrows indicate upstream signaling pathways converging on select transcription factors, or experimentally validated interactions between transcription factors. BRD14 (bromodomain containing protein 4), Ca2+ (calcium), ECM (extracellular matrix), EMT (epithelial-to-mesenchymal transition), HIF1α (hypoxia inducible factor 1 alpha), MAPK (mitogen-activated protein kinase), MRTF (myocardin-related transcription factor), ROCK (Rho-kinase), ROS (reactive oxygen species), SRF (serum response factor), TAZ (transcriptional coactivator with PDZ-binding motif), TGF-β (Transforming growth factor beta), TRPC6 (transient receptor potential cation channel subfamily C member 6), YAP (Yes-associated protein).