Figure 1.

(A) Injection scheme to induce CIPN. (B) PWT measured for mechanical allodynia test using von Frey filament and PWT on the 7th day of the experiment (n = 5). (C) Histology of hind paw skin of a mouse on 7th day; scale bar represents 50 μm in length (n = 4). (D) Epidermal thickness length measured. Vincristine- and oxaliplatin-treated mice were compared to the sham mice. (E) Number of cells counted per 0.01 mm² in the epidermis and dermis layer (n = 9). Results are presented as the mean ± SEM (## p < 0.01, ### p < 0.001, *** p < 0.001, ANOVA, followed by Bonferroni post hoc test).