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. 2023 Jan 17;24(3):1821. doi: 10.3390/ijms24031821

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Principal component analysis of normalized and filtered gene expression data. Dot fill colors indicate the medium used to culture keratinocytes (gray: Surge SFM and white: ckDME-Ham). Dot shapes identify keratinocyte populations (k3: triangle, k4: square, k5: pentagon, and k6: hexagon). Dotted ellipses represent both medium type clusters. (B) Volcano plot illustrating the results of the paired differential analysis of gene expression between keratinocytes cultured with Surge SFM and those cultured with ckDME-Ham. Dots represent individual genes. Gray genes’ expression was not significantly altered by culturing keratinocytes with Surge SFM rather than ckDME-Ham as opposed to colored genes whose expression was significantly (p < 0.05) modified by at least a 2-fold change in either direction (green: downregulated and red: upregulated).