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[Preprint]. 2023 Feb 5:2023.02.03.526066. [Version 1] doi: 10.1101/2023.02.03.526066

Figure 2. Distilled evidence supporting T1D candidate genes in the T1DKP.

Figure 2.

The T1DKP provides distillations of human genetic results for researchers who are not experts in human genetics. (A) The summary page for the CTLA4 gene provides evidence that this gene affects T1D risk, including results providing ‘very strong’ support from the HuGE calculator (Dornbos et al) and strong evidence for T1D association from MAGMA analyses (de Leeuw et al). (B) A ‘T1D effector genes’ list (Onengut-Gumuscu and Rich) predicts CTLA4 as a ‘causal’ gene for T1D based on genetic, perturbational, and gene regulatory evidence.