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[Preprint]. 2023 Feb 5:2023.02.03.526066. [Version 1] doi: 10.1101/2023.02.03.526066

Figure 3. Predicting causal mechanisms at T1D risk loci in the T1DKP.

Figure 3.

Predicting causal mechanisms at the 6q15 locus. (top) Prioritizing variants with evidence for affecting T1D risk based on significant association and 99% credible sets. (middle) Prioritizing variants overlapping cCREs active in T1D-enriched cell types and tissues. (bottom) Prioritizing genes linked to variants in cCREs in specific cell types and tissues. From these analyses two variants are predicted as causal candidates for T1D risk at this locus, which are linked to multiple candidate genes including BACH2 in immune cells.