Fig. 1. Comparison of modification reaction kinetics for authentic tRNA transcripts and tRNAs embedded within 5’- and 3’-end hairpins.
A, Structure and sequence of the in vitro transcription template containing 5’- and 3’-hairpins on each side of the tRNA. The RT primer binding site in the 3’-region is also indicated B, Single-turnover reaction plots for authentic tRNA transcripts (wild-type; circles) and SHAPE tRNAs (5’/3’-linkers; squares) for tRNAGly-GCC (left), tRNATrp-CCA (middle), and tRNAVal-UAC (right).
