Table 1:

Simulation lengths of all-atom lipid bilayers used in this work. The calculations based on enhanced-sampling simulations entailed multiple replicas with increasing degrees of applied curvature, carried out in parallel.

Composition	Conventional MD sampling time (single replica), μs			Multi-Map enhanced MD sampling time (replica count × time), μs
POPC	5.3	5.9	3.3	13 × 0.3	12 × 0.6	12 × 1.5
POPC/CHOL	8.9	9.1	3.4	13 × 0.7	14 × 0.7	13 × 1.5
DOPC	2.0	6.5	3.3	15 × 0.1	14 × 0.7	13 × 1.5
DOPC/CHOL	6.2	7.5	3.4	12 × 0.7	15 × 0.6	13 × 1.5
Number of lipids per unit cell	1800	800	200	1800	800	200