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[Preprint]. 2023 Apr 21:2023.02.03.527065. Originally published 2023 Feb 4. [Version 3] doi: 10.1101/2023.02.03.527065

Figure 1. Characteristics of tissue-specific Numts in post-mortem human brain regions and blood.

Figure 1.

(A) Overview of approach to identify tissue-specific Numts in ROSMAP cohort. (B) Abundance of tissue-specific Numts across brain regions and blood cells from ROSMAP participants. (C) Effect size (Hedge’s g) of average tissue-specific Numts relative to peripheral blood mononuclear cells (PBMC). (D) Length of tissue-specific Numts across brain regions and whole-blood. (E) Genic distribution of tissue-specific Numts versus the expected distribution in the whole-genome for all samples (pie charts) and delineated by brain regions and whole-blood (bar charts). (F) Random genomic distributions of tissue-specific Numts across tissues (left), cognitive impairment stratifications (middle), and age groups (right), based on comparison to simulation data. The age groups were defined as less than 85 (n=295), between 85 to 93 (n=545), and greater than or equal to 93 (n=319). Student’s t-test was used to test the significance in B and D. Pearson’s chi-square test was used to test the significance in E. Fisher’s exact test was employed instead of Pearson’s chi-square test when sample sizes are small. ***, **, and * represent a significant p-value less than 0.001, 0.01, and 0.05, respectively.