Figure 2. Numt association with age at death by tissue and cognitive impairment.

(A) Correlation between age at death and abundance of DLPFC-specific, cerebellum-specific, and PCC-specific Numts, respectively. (B) DLPFC samples correlated with age at death, stratified by cognitive diagnosis status as no cognitive impairment (NCI, n=121, left), mild cognitive impairment (MCI, n=112, middle), and Alzheimer’s disease (AD, n=176, right). Data points are colored by arbitrary age groups (see Methods) in light yellow, orange, and brown, respectively. r² and p-values are calculated using standard least-squares regression models.