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[Preprint]. 2023 Apr 21:2023.02.03.527065. Originally published 2023 Feb 4. [Version 3] doi: 10.1101/2023.02.03.527065

Figure 3. Numts accumulate in human fibroblasts during normal aging.

Figure 3.

(A) Study design of cellular aging model using primary fibroblasts from three healthy donors. (B) Numts accumulate over time in aging fibroblasts obtained from three healthy donors cultured up to 211 days, with left y-axis and circle dots representing cell-line specific variation, and right y-axis and triangle dots representing total accumulated variations from each cell line. (C) Heatmap of slopes based on the linear regression between days cultured and the cell-line specific calls, including Numts (from Dinumt, left) and structural variants (from DELLY, right). (D) Time-course of cell-line specific and whole-genome overall genomic deletions in the three healthy donors, with axis labels the same as in (B).